The Astros’ offense is taking a sizable hit, as the team announced Wednesday that designated hitter Yordan Alvarez, third baseman Alex Bregman, second baseman Jose Altuve, catcher Martin Maldonado and infielder Robel Garcia are all going to the injured list. The team made the moves due to health and safety protocols, according to Astros general manager James Click, who doesn’t expect their game against the Tigers on Wednesday to be postponed, Mark Berman of Fox 26 tweets.

Houston’s losing four regulars in Alvarez, Bregman, Altuve and Maldonado. The first three have been vital members of the Astros’ offense for multiple seasons, and all three have gotten off to strong starts this year. Maldonado isn’t nearly as effective at the plate, though the Astros like his defense enough that they had been finalizing a one-year extension with him as of Tuesday.

With such a large chunk of their position player group down, the Astros are bringing up infielders Abraham Toro, Alex De Goti and Taylor Jones, catcher Garrett Stubbs, and outfielder Ronnie Dawson. De Goti and Dawson weren’t on the Astros’ 40-man roster, so their contracts had to be selected.